chondro.site Literature Home cyto.site

Literature / Library

Library

13 pictures and 105 papers on the chondrocyte: the pictures by method, the papers by section. A picture opens large on a click and goes to its paper on a second. Every PMID chondro.site cites (191) is checked against PubMed for retractions at each build: none found.

Electron microscopy 3

Hyaline cartilage TEM. Chondrocytes arranged in chondrons contain extensive rough endoplasmic reticulum (RER); surrounding matrix shows type II collagen fibrils interspersed with proteoglycans. Six-day-old mouse, demineralized bone.

Michael J.F. Blumer · CC BY 4.0

Human articular chondrocyte TEM (non-loading control arm). Panel A: autophagosomes, lysosomes, and autolysosomes showing normal autophagy activity. From a study of mechanical loading effects on OA chondrocytes; non-loading arm is the baseline control.

Sato, Iwata, Yamamoto et al 2026, Int J Mol Sci · CC BY 4.0

Human growth plate chondrocyte TEM. Resting zone (RZ) and proliferative zone (PZ) chondrocytes showing heterochromatin (asterisks) and lysosomes (arrowheads). Panel b from a study of cellular quiescence in the resting zone.

Avijgan, Lopez-Perez, Galicia et al 2026, Bone Research · CC BY 4.0

Immunostaining and fluorescence 2

Tibial plateau articular cartilage, spontaneous OA. Safranin O and IHC for CollagenX, MMP-13, Aggrecan, Caspase-3 across age groups. Scale bar 100 um.

Wang, Wei, Xue et al 2021, BMC Musculoskeletal Disorders · CC BY 4.0

Ferroptosis is activated in osteoarthritic chondrocytes and contributes to cartilage degeneration (A) Heatmap of whole-transcriptome sequencing comparing normal chondrocytes and OA chondrocytes. (B) Volcano plot showing differentially expressed ferroptosis-related genes. (C) GO enrichment analysis indicating dysregulation of iron homeostasis and glutathione metabolism in OA. (D) Immunohistochemical (IHC) staining of human OA cartilage and mouse cartilage tissues showing ACSL4 and GPX4 expression. Scale bars, 200 μm.

Mai, Zhu, Liu et al 2026, iScience · CC BY 4.0

Stained sections and smears 4

Hyaline cartilage histological section, H&E stain. Chondrocytes in lacunae visible within the cartilage matrix.

Nbnidhi · CC BY 4.0

Safranin-O/Fast Green staining of knee articular cartilage. Red areas indicate preserved cartilage proteoglycans; green areas show depletion. From a DMM-induced OA model study of FGF9 intra-articular delivery.

Lo, Chen, Huang et al 2026, Bone and Joint Research · CC BY 4.0

Human osteochondral explant H&E. Preserved (normal), lesioned (OA), and treated cartilage regions in the same section. Subchondral bone visible beneath cartilage.

Sayedipour, Mazzini, Tuerlings et al 2026, Osteoarthritis and Cartilage Open · CC BY 4.0

Histological cartilage evaluation in femoral condyles. Representative hematoxylin-eosin-stained sections of osteaoarthritic (OA) femoral condyles and their contralateral healthy (HT) from (A,D) SHAM: sham surgery, treated with placebo; (B,E) CONT: control, operated knees treated with placebo; (C,F) ASU: operated knees treated with avocado/soybean unsaponifiables. (G) The bar graph shows semiquantitative histological scores for cartilage structure (CART), chondrocyte abnormalities (CHOND), tidemark integrity (TIDEMARK), and total score (TOTAL) in the previously mentioned groups. Asterisks (*) indicate significant differences with the contralateral HT joint and the hash (#) indicates significant differences with the SHAM-OA group. Four-point stars denote chondrocyte clusters, black arrows denote empty lacunae, and dashed arrows denote surface undulations and irregularities.

Sabucedo-Suarez, Munoz, Permuy et al 2026, Frontiers in Veterinary Science · CC BY 4.0

Other micrographs 1

Articular cartilage ECM zonal architecture. Superficial zone: collagen II fibers aligned parallel to articular surface (resists shear). Deep zone: fibers aligned perpendicular to bone interface (absorbs compression).

Bautista, Park, Mazur, Aaron, Bilgen · CC0

Figures and diagrams 3

Chondrocyte in its lacuna. Territorial matrix (type VI collagen capsule) and interterritorial matrix (type II collagen, aggrecan, hyaluronan) shown.

Chondro / chondro.site · CC0

Articular cartilage zones: superficial (tangential), middle (transitional), deep (radial), calcified, and subchondral bone. Collagen fiber orientation shown per zone.

Chondro / chondro.site · CC0

Growth plate zones: resting, proliferating, hypertrophic, calcified cartilage, and primary spongiosa.

Chondro / chondro.site · CC0

Signaling 23

Filed by MeSH heading or keyword; each paper says which one matched. The Signaling page holds the dated feed.

  1. Wang ZL, Li HB, Li YT. Combined in vitro microcurrent stimulation and celecoxib suppress NF-κB/NLRP3 signaling and cartilage catabolism in human chondrocytes. Immunol Res. 2026;74:115. PMID: 42789005. MeSH: Signal Transduction
  2. Wei X, Guan B, He X, Zhu S, Bi R. Role of Notch signaling pathway in joint homeostasis and osteoarthritis. Front Bioeng Biotechnol. 2026;14:1861292. PMID: 42769654. keyword: Notch signaling pathway
  3. Zhang L, Yang X, Yu Y, Yang L. Mammalian cell-derived extracellular vesicles remodel the immune-repair microenvironment in osteoarthritis: from pathological signal transmission to regenerative therapy. Front Immunol. 2026;17:1936617. PMID: 42756019. MeSH: Signal Transduction
  4. Zhu G, Yang Y, Ma Y, Wu G, Tian K, He X, et al. Artemotil Attenuates Fibrosis-Associated Chondrocyte Remodelling in Osteoarthritis in Association With STC1-Related TGF-β/SMAD2/3 Signalling. J Cell Mol Med. 2026;30:e71374. PMID: 42747683. MeSH: Signal Transduction
  5. Toumi H, Almhdie-Imjabbar A, Lespessailles E. Piezo1 as a Key Mechanosensitive Ion Channel Linking Mechanical Overload to Mitochondrial Dysfunction, Mitophagy, and Immunometabolic Dysregulation in Osteoarthritis. Cells. 2026;15:1511. PMID: 42738805. keyword: calcium signaling
  6. Wang Y, Wang Y, Li S, Chen X, Hou Y, Wang C, et al. Eugenol preserves chondrocyte extracellular matrix homeostasis by modulating the ALK1/ALK5-associated TGF-β/Smad signaling axis. Front Pharmacol. 2026;17:1885138. PMID: 42723961. keyword: SMAD signaling
  7. Hu H, Li G, Wang Y, Xie S, Cao F, Li H, et al. Secoisolariciresinol diglucoside alleviates inflammatory injury in osteoarthritis chondrocytes through ERBB2-associated JAK2/STAT3 signaling: network pharmacology and experimental validation. Front Immunol. 2026;17:1891212. PMID: 42718780. MeSH: Signal Transduction
  8. Valerio HP, Corrêa de Melo T, Barbosa de Souza Rizzo M, Teixeira de Melo A, Alvarez-Flores MP, Chudzinski-Tavassi AM. Proteomic Dynamics Reveal Cell-Cycle and Rho GTPase Remodeling Associated with Transient Senescence Traits in Human Chondrocytes During Sustained IL-1β Signaling. Cells. 2026;15:1431. PMID: 42645159. MeSH: Signal Transduction
  9. Yang L, Feng J, He W, Huang Y. Prim-O-glucosylcimifugin alleviate osteoarthritis through regulates autophagy via IGF1R/JAK2/STAT3 axis. Phytomedicine. 2026;161:158571. PMID: 42636684. MeSH: Signal Transduction
  10. Yuan S, Chen H, Wei J, Tan J, Liu S, Fu Z. Integrated single-cell and experimental validation links effector chondrocyte-associated oxidative stress to EIF6-related p47phox-NOX2 signaling in osteoarthritis. Front Physiol. 2026;17:1882484. PMID: 42630363. keyword: p47phox–NOX2 signaling
  11. Gui Y, Ma R, Ma L, Zou T, Zhang K, Guo X. Fluoride induced chondrocyte extracellular matrix degradation by inhibition of glycolysis by the PHD2/HIF1α signaling pathway. Environ Toxicol Pharmacol. 2026;126:105140. PMID: 42628705. MeSH: Signal Transduction
  12. Li W, Wang Q, Gu X, Chen M, Xu Q, Li D, et al. Metasurface-enhanced surface plasmon resonance microscopy for long-term label-free monitoring of chondrocyte-biointerface dynamics under mechanical, genetic, and inflammatory perturbations. Colloids Surf B Biointerfaces. 2026;268:116084. PMID: 42607386. keyword: Wnt/β-catenin signaling
  13. Widowati W, Lydia L, Rumayauw J G, Wijaya MP, Caroline S S M, Putera JH, et al. Secretome Derived from Umbilical Cord Mesenchymal Stem Cells as a Therapeutic Approach for Osteoarthritis: Insights from In Vitro, In Vivo, and Clinical Evidence. Cell Biochem Biophys. 2026;84:3319-3332. PMID: 42601565. keyword: Paracrine signaling
  14. Luo F, Yuan X, Zhou H, Wang Q, Chen C, Ling Y, et al. Extracellular vesicle-mediated immune crosstalk in rheumatoid arthritis synovium: mechanistic insights and translational challenges. Front Immunol. 2026;17:1891984. PMID: 42598067. MeSH: Signal Transduction
  15. Zhang X, Gong C, Zhou J, Zhang Y, Jiang H, Yang Y, et al. Methylnissolin preserves chondrocyte homeostasis and attenuates experimental osteoarthritis through modulation of the PI3K-AKT-NF-κB signaling axis. Int Immunopharmacol. 2026;187:117245. PMID: 42567109. MeSH: Signal Transduction
  16. Mai L, Zhu R, Liu Y, Feng J, Huang M, Yin M, et al. Mechanism of RORα in promoting osteoarthritis through p53 deubiquitination-mediated chondrocyte ferroptosis. iScience. 2026;29:116939. PMID: 42565176. keyword: retinoic acid-related orphan receptor alpha
  17. Zhang Z, Zhang C, Ju Y, Zhou Y, Guo W, Xie J, et al. Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming. Proc Natl Acad Sci U S A. 2026;123:e2602136123. PMID: 42546205. MeSH: MAP Kinase Signaling System
  18. Yang J, Kubav A. Circular RNAs orchestrate molecular networks in osteoarthritis: From miRNA sponging to epigenetic and exosome-mediated regulation. Mol Biol Rep. 2026;53:1322. PMID: 42545381. MeSH: Signal Transduction
  19. Jain M, Anuja AK, Yadav S, Ara J, Ojha A, Chaturvedi CP. Non-coding RNA in osteoarthritis: mechanistic insights and future perspectives. Front Endocrinol (Lausanne). 2026;17:1851589. PMID: 42523837. MeSH: Signal Transduction
  20. Pan J, Wang X, Gao Y, Ma Y, Ma J, Wang Z. DINCH exposure contributes to osteoarthritis pathogenesis via TSPO-mediated chondrotoxicity: Evidence from in silico prediction to experimental validation. Chem Biol Interact. 2026;437:112266. PMID: 42501774. MeSH: Receptors, GABA
  21. Hao D, Lu W, Wang F, Zhang L. Exercise therapy-associated changes in Periostin (POSTN) osteoarthritis are linked to Hippo-YAP signaling. Mol Biol Rep. 2026;53:1232. PMID: 42484941. MeSH: YAP-Signaling Proteins
  22. Kulyar MF, Pachaleva J, Brazaite S, Akhtar M, Hasan MM, Kaboli S, et al. Signal-driven interplay between lipid peroxidation and ferroptosis orchestrates osteoarthritis degeneration. J Orthop Translat. 2026;60:101178. PMID: 42471867. keyword: Chondrocyte signalling
  23. Ai X, Zhu C, Xie Y, Luo X, Zhang C. ITGB1-Mediated Focal Adhesion Signaling Underlies the Chondroprotective Effects of Extracorporeal Shockwave Therapy in Knee Osteoarthritis. Am J Phys Med Rehabil. 2026;105:704-713. PMID: 42468008. MeSH: Signal Transduction

Disorders 79

Filed by MeSH heading or keyword; each paper says which one matched. The Disorders page holds the dated feed.

  1. Su H, Zhu Q, Xiang J, Wu Q, Sun W, Fang J, et al. Hierarchical Nanorocket for spatially coordinated regulation of glycosaminoglycan deposition and metabolism in cartilage. Bioact Mater. 2027;68:148-161. PMID: 42733560. keyword: Osteoarthritis intervention
  2. Wang ZL, Li HB, Li YT. Combined in vitro microcurrent stimulation and celecoxib suppress NF-κB/NLRP3 signaling and cartilage catabolism in human chondrocytes. Immunol Res. 2026;74:115. PMID: 42789005. MeSH: Osteoarthritis
  3. Li Z, Lv Y, Li W, Guo Z, Huang Z, Wei M, et al. Infrapatellar fat pad exosomes promote osteoarthritis by reprogramming macrophage polarization. Biomaterials. 2026;338:124643. PMID: 42785223. keyword: Osteoarthritis
  4. Vescio RR, Fiordalisi MF, Ambrosio L, Fiorentino D, de Rinaldis E, Di Giacomo G, et al. Irisin in Cartilage Homeostasis: Molecular Mechanisms and Therapeutic Implications for Osteoarthritis. J Funct Morphol Kinesiol. 2026;11:343. PMID: 42783637. keyword: inflammation
  5. Guo Y, Zhang X, Zhao S, Bian C, Zhu M, Su C, et al. Therapeutic Effects of WIN55,212-2 on Temporomandibular Joint Osteoarthritis in a Rat Model and Primary Temporomandibular Joint Condylar Chondrocytes. Curr Med Chem. 2026. PMID: 42770450. keyword: Temporomandibular joint osteoarthritis
  6. Wei X, Guan B, He X, Zhu S, Bi R. Role of Notch signaling pathway in joint homeostasis and osteoarthritis. Front Bioeng Biotechnol. 2026;14:1861292. PMID: 42769654. keyword: osteoarthritis
  7. Shodiev DR, Zvyagina VI, Shchul'kin AV, Marsyanova YA, Ryabova MN, Belskikh ES. Analysis of SUCNR1 in Cartilage Tissue and Its Association with Succinate Metabolism in the Metabolic Phenotype of Osteoarthritis. Bull Exp Biol Med. 2026. PMID: 42768252. keyword: osteoarthritis
  8. Liu J, Ke H, Su L, Lin Z, Liu C, Jiang S, et al. Yam-Derived Vesicles Alleviate Osteoarthritis via miRNA-Mediated Suppression of the TLR4-TRAF6 Signaling Axis. Small. 2026:e75914. PMID: 42766346. keyword: osteoarthritis
  9. Das S, Swain P, Swain S, Misra RDK, Rautray TR. Epidemiology and potential mechanisms of structural progression in osteoarthritis. Artif Cells Nanomed Biotechnol. 2026;54:781-818. PMID: 42762435. MeSH: Osteoarthritis
  10. Zhang Z, Wang J, Bian H, Chen J, Wang J, Sun Y, et al. Revealing the bioactive components and possible mechanism of Tongbi Lingding in the treatment of osteoarthritis based on UPLC-MS/MS, network pharmacology, transcriptomics, molecular docking, and experimental validation. Naunyn Schmiedebergs Arch Pharmacol. 2026. PMID: 42760374. keyword: Osteoarthritis
  11. Zhang L, Yang X, Yu Y, Yang L. Mammalian cell-derived extracellular vesicles remodel the immune-repair microenvironment in osteoarthritis: from pathological signal transmission to regenerative therapy. Front Immunol. 2026;17:1936617. PMID: 42756019. MeSH: Osteoarthritis
  12. Xu J, Wang W, Liu L, Wang C, Liu N, Wang X, et al. The application of novel ultrathin iron sulphide nanosheets in the nanotherapy of post-traumatic osteoarthritis. Mater Today Bio. 2026;40:103630. PMID: 42750882. keyword: Osteoarthritis
  13. Zhu G, Yang Y, Ma Y, Wu G, Tian K, He X, et al. Artemotil Attenuates Fibrosis-Associated Chondrocyte Remodelling in Osteoarthritis in Association With STC1-Related TGF-β/SMAD2/3 Signalling. J Cell Mol Med. 2026;30:e71374. PMID: 42747683. MeSH: Chondrocytes/pathology
  14. Liang Z, Sun Q, Song D, Jia X, Han C, Han J, et al. Fabrication of a novel carboxymethyl chitosan-manganese complex and its multidimensional regulatory effects on the joint microenvironment in early osteoarthritis. Biomater Adv. 2026;190:215169. PMID: 42743824. keyword: Anti-inflammation
  15. Lu X, Wang Z, Hu W, Hu J, Zou Y. Ginsenoside Rg3 attenuates osteoarthritis progression by modulating the Nrf2-mediated autophagy pathway. Connect Tissue Res. 2026:1-18. PMID: 42742542. keyword: Osteoarthritis
  16. Toumi H, Almhdie-Imjabbar A, Lespessailles E. Piezo1 as a Key Mechanosensitive Ion Channel Linking Mechanical Overload to Mitochondrial Dysfunction, Mitophagy, and Immunometabolic Dysregulation in Osteoarthritis. Cells. 2026;15:1511. PMID: 42738805. MeSH: Osteoarthritis
  17. Nakamura K, Fujii Y, Arai Y, Nakagawa S, Inoue A, Cha R, et al. HIF-PH Inhibitor Promotes Stabilization of HIF-1α via Inhibition of Its Degradation and Exerts Chondroprotective Effects in a Rat Osteoarthritis Model. Int J Mol Sci. 2026;27:7869. PMID: 42737766. MeSH: Osteoarthritis
  18. Chen YX, Zhang F, Ding Y, Zheng MH, Zhou ZA, Qiu L, et al. Advances in drug delivery systems for Osteoarthritis therapy: exosomes, microparticles, nanoparticles, and hydrogels. Discov Nano. 2026;21:440. PMID: 42734879. keyword: Osteoarthritis
  19. Zhang Z, Li Y, Ye M, Liu H, Huang Q, Wang X, et al. A biomimetic chondrocyte membrane-camouflaged tFNA nanoplatform for reprogramming the cartilage-synovium axis in osteoarthritis. Mater Today Bio. 2026;40:103609. PMID: 42733614. keyword: Osteoarthritis
  20. Liu H, Yao D, Wang Y, Kong Q. SERPINE1/PAI-1 in Skeletal Degeneration: A Proposed Context-Dependent Framework for Bone Remodeling Regulation. Calcif Tissue Int. 2026;117:138. PMID: 42726129. MeSH: Osteoarthritis
  21. Wang Y, Wang Y, Li S, Chen X, Hou Y, Wang C, et al. Eugenol preserves chondrocyte extracellular matrix homeostasis by modulating the ALK1/ALK5-associated TGF-β/Smad signaling axis. Front Pharmacol. 2026;17:1885138. PMID: 42723961. keyword: osteoarthritis
  22. Khaliji E, Wong TS, Barker CM, Chen S, Cassano JM. Non-coding RNA profiles associated with equine osteoarthritis: a systematic review. Front Vet Sci. 2026;13:1917722. PMID: 42719329. keyword: osteoarthritis
  23. Hu H, Li G, Wang Y, Xie S, Cao F, Li H, et al. Secoisolariciresinol diglucoside alleviates inflammatory injury in osteoarthritis chondrocytes through ERBB2-associated JAK2/STAT3 signaling: network pharmacology and experimental validation. Front Immunol. 2026;17:1891212. PMID: 42718780. MeSH: Chondrocytes/pathology
  24. Zhong H, He Q, Qin F, Shu Y, Wang Y, Yang X, et al. In situ-built chemo-electroactive hydrogel incorporating Mg-based hydrogen generators for osteoarthritis therapy. Mater Today Bio. 2026;40:103604. PMID: 42718625. keyword: Anti-inflammation
  25. Xia D, Li J, Zhou X, Yu C, Yang S. DOT1L-mediated H3K79me3 of ITCH promotes AURKA ubiquitination to suppress ECM degradation in osteoarthritis. Mol Genet Genomics. 2026;301:188. PMID: 42714638. MeSH: Osteoarthritis
  26. Wang T, Liu Y. Vestitol Ameliorates Ferroptosis-Associated Features and Osteoarthritis Progression Through Modulation of the GSK3B/Nrf2/GPX4 Pathway. Cell Biochem Biophys. 2026. PMID: 42711652. keyword: Inflammation
  27. Novotný R, Rajzer I, Franková J. In vitro evaluation of hydroxyapatite, β-tricalcium phosphate, graphene oxide and zinc oxide for osteochondral regeneration under inflammatory conditions. Mol Cell Biochem. 2026. PMID: 42709332. keyword: Inflammation
  28. Chen S, Yang S, He J, Wang Y, Liu Z, Wu J, et al. Chlorogenic acid protects against knee osteoarthritis by targeting the Nrf2/HO-1 redox-ferroptosis axis and inflammatory cartilage degeneration. Int Immunopharmacol. 2026;189:117382. PMID: 42705065. keyword: Knee osteoarthritis
  29. Ji C, Niu C, Liu Q, Chen Y, Zeng Q, Chen Y. Chondroitin sulfate and collagen peptides co-derived from sturgeon cartilage: Characterization and combined effects on IL-1β-induced chondrocyte inflammation in vitro. Int J Biol Macromol. 2026;382:154169. PMID: 42702320. keyword: Osteoarthritis
  30. Yue H, Alhaskawi A, Ezzi SHA, Zhou J. Biologic and regenerative strategies for osteoarthritis: advances in MSC, exosome, and PRP based therapies. Front Pharmacol. 2026;17:1897284. PMID: 42694831. keyword: osteoarthritis
  31. Ragni E, Taiana M, Landoni S, Valli F, Nebuloni AM, De Luca P, et al. Matrix Protective and Anti-Inflammatory In Vitro Potential of Adipose Mesenchymal Stromal Cell-Derived EVs Coupled With Platelet-Derived Fibrin Gel. Front Biosci (Landmark Ed). 2026;31:54998. PMID: 42689990. MeSH: Osteoarthritis
  32. Wang Y, Kang L, Chen K, Jiang Y, Zheng Y, Xu P, et al. ROS-responsive injectable hydrogel enables controlled release of human adipose tissue-derived extracellular vesicles for multifaceted osteoarthritis therapy. J Nanobiotechnology. 2026;24:829. PMID: 42687185. MeSH: Osteoarthritis
  33. Gao S, Huo X, Shen P, Ma J, Ma X. CSNK2A2 drives knee osteoarthritis progression by co-activating the Wnt/β-catenin and NF-κB signaling pathways. Arch Biochem Biophys. 2026;786:110986. PMID: 42674201. keyword: Knee osteoarthritis
  34. He Y, Li C, Chen K, Wang X, Xu S, Zhou Z, et al. MYDGF as a telomerase activator and therapeutic target for osteoarthritis. Adv Biotechnol (Singap). 2026;4:34. PMID: 42671689. keyword: Osteoarthritis (OA)
  35. Zhou R, Li J, Chen S, Meng C, Liu Q, Huang X, et al. Corilagin attenuates osteoarthritis progression by coordinating NF-κB inhibition with PI3K/AKT/mTOR-associated autophagy restoration. Int Immunopharmacol. 2026;188:117342. PMID: 42664894. keyword: Inflammation
  36. He X, Guo M, Lian H, Chen L. Mesenchymal Stem Cell Exosomes in Combination with Hydrogels for Osteoarthritis: From Exploratory Applications to Optimization and Translational Outlook. Curr Issues Mol Biol. 2026;48:764. PMID: 42651763. keyword: osteoarthritis (OA)
  37. Gao J, Xue Z, Qiu H, Chen C, Li C. Bai@Cu-MOF alleviates osteoarthritis by targeting ferroptosis and restoring chondrocyte redox balance. Int J Biol Macromol. 2026;381:154214. PMID: 42648682. keyword: Osteoarthritis
  38. Raja K, Suresh DG, Albeshri JK, Rawat SS, Prithishkumar IJ, Nau T, et al. Inflammation-Associated Changes in Piezo1 Expression, Mitophagy-Related Markers, and Matrix Dysregulation in an LPS-Stimulated Co-Culture Organoid System. Cells. 2026;15:1482. PMID: 42645208. MeSH: Inflammation
  39. Valerio HP, Corrêa de Melo T, Barbosa de Souza Rizzo M, Teixeira de Melo A, Alvarez-Flores MP, Chudzinski-Tavassi AM. Proteomic Dynamics Reveal Cell-Cycle and Rho GTPase Remodeling Associated with Transient Senescence Traits in Human Chondrocytes During Sustained IL-1β Signaling. Cells. 2026;15:1431. PMID: 42645159. keyword: chronic inflammation
  40. Du G, Wang D, Chen Q, Sun J, Shuai Q, Zhang Q, et al. A stiffness-tunable 3D alginate-collagen-hyaluronic acid model reveals the matrix-dependent chondroprotection of quercetin in osteoarthritis. Biomater Adv. 2026;189:215130. PMID: 42641414. MeSH: Osteoarthritis
  41. Wells LM, Keen JAC, Sharma A, Marr N, Hansen R, Pereira JS, et al. Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis. Bone Res. 2026;14:89. PMID: 42637709. MeSH: Chondrocytes/pathology
  42. Yang L, Feng J, He W, Huang Y. Prim-O-glucosylcimifugin alleviate osteoarthritis through regulates autophagy via IGF1R/JAK2/STAT3 axis. Phytomedicine. 2026;161:158571. PMID: 42636684. MeSH: Osteoarthritis
  43. Zhang R, Zhang W, Ou S, Xu C, Qi Y, Yang Y. VHL/CDO1 axis regulates chondrocyte ferroptosis and knee osteoarthritis progression. Arch Biochem Biophys. 2026;785:110980. PMID: 42632536. MeSH: Chondrocytes/pathology
  44. Yuan S, Chen H, Wei J, Tan J, Liu S, Fu Z. Integrated single-cell and experimental validation links effector chondrocyte-associated oxidative stress to EIF6-related p47phox-NOX2 signaling in osteoarthritis. Front Physiol. 2026;17:1882484. PMID: 42630363. keyword: osteoarthritis
  45. Safiyyu MU, Syed NH, Azlan M, Zain MRAM, Nurul AA. MicroRNAs as Key Regulators of Degeneration and Inflammation in Osteoarthritis: A Narrative Review. Saudi J Med Med Sci. 2026;14:197-208. PMID: 42621662. keyword: inflammation
  46. Iqbal Z, Shabbir M, Rasul F, Xia J, Zeng H, Liang Y, et al. Extracellular matrix targeting peptide functionalized plant-derived lipid nanoparticles for gene therapy in osteoarthritis. Chin Med J (Engl). 2026. PMID: 42619364. keyword: Osteoarthritis
  47. Yuan XS, Zhang HJ, Ding JX, Luo ZL, Chen M, Zhang XQ, et al. IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m6A-Dependent Stabilization of ECM1 mRNA. Kaohsiung J Med Sci. 2026:e70280. PMID: 42618981. keyword: osteoarthritis
  48. Li W, Wang Q, Gu X, Chen M, Xu Q, Li D, et al. Metasurface-enhanced surface plasmon resonance microscopy for long-term label-free monitoring of chondrocyte-biointerface dynamics under mechanical, genetic, and inflammatory perturbations. Colloids Surf B Biointerfaces. 2026;268:116084. PMID: 42607386. MeSH: Inflammation
  49. Widowati W, Lydia L, Rumayauw J G, Wijaya MP, Caroline S S M, Putera JH, et al. Secretome Derived from Umbilical Cord Mesenchymal Stem Cells as a Therapeutic Approach for Osteoarthritis: Insights from In Vitro, In Vivo, and Clinical Evidence. Cell Biochem Biophys. 2026;84:3319-3332. PMID: 42601565. MeSH: Osteoarthritis
  50. Luo F, Yuan X, Zhou H, Wang Q, Chen C, Ling Y, et al. Extracellular vesicle-mediated immune crosstalk in rheumatoid arthritis synovium: mechanistic insights and translational challenges. Front Immunol. 2026;17:1891984. PMID: 42598067. MeSH: Arthritis, Rheumatoid
  51. Tang R, Yin J, Li S, Wang S, Fei J, Zhou Z. Mitochondrial dysfunction as a key mediator of endplate chondrocyte senescence: emerging insights and targeted interventions. Exp Gerontol. 2026;223:113276. PMID: 42595025. MeSH: Mitochondria/pathology
  52. Wang Z, Shi X, Yang G, Zheng K, Xu R. Sex hormones and their receptors in osteoarthritis: current research progress. Ann Jt. 2026;11:43. PMID: 42591740. keyword: Osteoarthritis (OA)
  53. Dalton J, Divi SN, Eichbaum YK, Luksanapruksa P, Ng MK, Huang R, et al. The Biological Response of Human NP Cells to Soluble Collagen VI. Cells. 2026;15:1339. PMID: 42587749. MeSH: Nucleus Pulposus/pathology
  54. Shao H, Lei Z, Yang W, Zhou J, Li Q, Xu S, et al. Immunomodulatory thermosensitive hydroxypropyl chitin hydrogel platform maintains cartilage-synovium homeostasis for enhanced osteoarthritis therapy. Bioact Mater. 2026;66:1167-1185. PMID: 42571192. keyword: Osteoarthritis
  55. Zhou Q, Shen Q, Gao Z, Shi W, Guo Q. HRX-215 attenuates cartilage fibrosis in osteoarthritis progression and microfracture repair by targeting MKK4. Biochem Pharmacol. 2026;254:118336. PMID: 42570848. keyword: Osteoarthritis
  56. Qiwei F, Jiahua S, Shu C, Jia C, Haobo L, Jun Z. Epigenetic-metabolic coupling by SOX3/WDR5-SIRT5 signaling mediates the therapeutic effects of TGFβ-targeted exosomal nanoparticles in osteoarthritis. Mater Today Bio. 2026;39:103457. PMID: 42569264. keyword: Osteoarthritis
  57. Zhang X, Gong C, Zhou J, Zhang Y, Jiang H, Yang Y, et al. Methylnissolin preserves chondrocyte homeostasis and attenuates experimental osteoarthritis through modulation of the PI3K-AKT-NF-κB signaling axis. Int Immunopharmacol. 2026;187:117245. PMID: 42567109. MeSH: Osteoarthritis
  58. Mai L, Zhu R, Liu Y, Feng J, Huang M, Yin M, et al. Mechanism of RORα in promoting osteoarthritis through p53 deubiquitination-mediated chondrocyte ferroptosis. iScience. 2026;29:116939. PMID: 42565176. keyword: osteoarthritis
  59. Faraldo NC, Ribeiro MDS, Apolonio EVP, Ferrari LC, Portugal LC, de Moura FBC, et al. Optimizing osteochondral decalcification and histological processing in ovine joint models. Braz J Vet Med. 2026;48:e013925. PMID: 42553617. keyword: orthopedic pathology
  60. Zhang Z, Zhang C, Ju Y, Zhou Y, Guo W, Xie J, et al. Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming. Proc Natl Acad Sci U S A. 2026;123:e2602136123. PMID: 42546205. MeSH: Osteoarthritis
  61. Yang J, Kubav A. Circular RNAs orchestrate molecular networks in osteoarthritis: From miRNA sponging to epigenetic and exosome-mediated regulation. Mol Biol Rep. 2026;53:1322. PMID: 42545381. MeSH: Osteoarthritis
  62. Jiang B, Jiang X, Li S, Niu H, Ji W. Curcumin-Loaded GelMA Microspheres Alleviate Osteoarthritis: Transcriptomic Evidence for Immune Microenvironment Remodeling and ECM Homeostasis Restoration. Chem Biol Drug Des. 2026;108:e70373. PMID: 42543780. MeSH: Osteoarthritis
  63. Maheshwari C, Reddy CB, Kodieswaran M, Nandi SK, Mandal BB. Compartmentalized Dual-Drug Injectable Hydrogel for Anti-Inflammatory Activity and Osteoarthritic Cartilage Repair. Small. 2026;22:e74820. PMID: 42535426. MeSH: Osteoarthritis
  64. Yang F, Wang Q, Zhu X, Yao Y, Yu T, Xiao X. Energy crisis and cartilage collapse: metabolic reprogramming of chondrocytes in osteoarthritis. Front Immunol. 2026;17:1834080. PMID: 42534542. MeSH: Osteoarthritis
  65. Liu Y, Zhang Y, Huang R, Bai L, Liu L, Wang C, et al. Contrasting Effects of HT-2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism. J Biochem Mol Toxicol. 2026;40:e71056. PMID: 42533448. MeSH: Chondrocytes/pathology
  66. Zhang L, Xing X, Zhou C, Fu F, Chen Z, Wu C, et al. Sophoridine attenuates osteoarthritis progression: association with suppression of chondrocyte pyroptosis via inhibiting NF-κB signaling pathway. Front Pharmacol. 2026;17:1861567. PMID: 42528752. keyword: inflammation
  67. Jain M, Anuja AK, Yadav S, Ara J, Ojha A, Chaturvedi CP. Non-coding RNA in osteoarthritis: mechanistic insights and future perspectives. Front Endocrinol (Lausanne). 2026;17:1851589. PMID: 42523837. MeSH: Osteoarthritis
  68. Mou Y, Tian T, Wang P, Wang X, Li W, Tang W, et al. Compressive stress-driven mechanosignaling in chondrocytes: From molecular mechanism to scaffold engineering and translational opportunities. Mater Today Bio. 2026;39:103453. PMID: 42518697. keyword: Osteoarthritis
  69. Zhao Y, Liu X. Epigenetic regulation in osteoarthritis: recent updates and emerging mechanisms. Front Genet. 2026;17:1862466. PMID: 42517028. keyword: osteoarthritis
  70. Pan J, Wang X, Gao Y, Ma Y, Ma J, Wang Z. DINCH exposure contributes to osteoarthritis pathogenesis via TSPO-mediated chondrotoxicity: Evidence from in silico prediction to experimental validation. Chem Biol Interact. 2026;437:112266. PMID: 42501774. MeSH: Osteoarthritis
  71. Chang Y, Kong K, Jin M, Liu S, Yang Y, Zhu Y, et al. Artificial Chlorella Biohybrids for Alleviation of Cartilage Degeneration in Osteoarthritis. Exploration (Beijing). 2026;6:20250125. PMID: 42494574. keyword: osteoarthritis
  72. Wang P, Tang W, Mou Y, Wang X, Li W, Niloy NR, et al. Mechanical sensing of fluid shear stress biphasically regulates chondrocyte metabolism and osteoarthritis progression: Implications for therapeutics. Prog Biophys Mol Biol. 2026;201:265-273. PMID: 42492727. MeSH: Chondrocytes/pathology
  73. Hao D, Lu W, Wang F, Zhang L. Exercise therapy-associated changes in Periostin (POSTN) osteoarthritis are linked to Hippo-YAP signaling. Mol Biol Rep. 2026;53:1232. PMID: 42484941. MeSH: Osteoarthritis
  74. Li T, Zheng A, Zhu C, Li Y, Yang Z, Tang X, et al. Mitochondria-targeted MXene-based nanozymes promote mitophagy and inhibit mtDNA-triggered cGAS/STING inflammation in osteoarthritis. Bioact Mater. 2026;66:412-427. PMID: 42473606. keyword: Osteoarthritis
  75. Kulyar MF, Pachaleva J, Brazaite S, Akhtar M, Hasan MM, Kaboli S, et al. Signal-driven interplay between lipid peroxidation and ferroptosis orchestrates osteoarthritis degeneration. J Orthop Translat. 2026;60:101178. PMID: 42471867. keyword: Osteoarthritis
  76. Dong H, Zhang X, Luo Y, Jin J, Luo Z, Lu Y. Mechanisms and research progress of statins in osteoarthritis. Int Immunopharmacol. 2026;186:117141. PMID: 42468167. MeSH: Osteoarthritis
  77. Ai X, Zhu C, Xie Y, Luo X, Zhang C. ITGB1-Mediated Focal Adhesion Signaling Underlies the Chondroprotective Effects of Extracorporeal Shockwave Therapy in Knee Osteoarthritis. Am J Phys Med Rehabil. 2026;105:704-713. PMID: 42468008. MeSH: Osteoarthritis, Knee
  78. Sabucedo-Suárez A, Muñoz F, Permuy M, Fernández-Martín S, Cantalapiedra-González A, López-Peña M. 27-Week avocado-soybean unsaponifiables treatment in a knee osteoarthritis rabbit model: histomorphometric assessment of potential disease-modifying effects. Front Vet Sci. 2026;13:1821515. PMID: 42290786. keyword: osteoarthritis
  79. Wilusz RE, Sanchez-Adams J, Guilak F. The structure and function of the pericellular matrix of articular cartilage. Matrix Biol. 2014;39:25-32. PMID: 25172825. MeSH: Cartilage, Articular/pathology

Medications 26

Filed by MeSH heading or keyword; each paper says which one matched. The Medications page holds the dated feed.

  1. Wang ZL, Li HB, Li YT. Combined in vitro microcurrent stimulation and celecoxib suppress NF-κB/NLRP3 signaling and cartilage catabolism in human chondrocytes. Immunol Res. 2026;74:115. PMID: 42789005. MeSH: Celecoxib/pharmacology
  2. Zhu G, Yang Y, Ma Y, Wu G, Tian K, He X, et al. Artemotil Attenuates Fibrosis-Associated Chondrocyte Remodelling in Osteoarthritis in Association With STC1-Related TGF-β/SMAD2/3 Signalling. J Cell Mol Med. 2026;30:e71374. PMID: 42747683. MeSH: Chondrocytes/drug effects
  3. Nakamura K, Fujii Y, Arai Y, Nakagawa S, Inoue A, Cha R, et al. HIF-PH Inhibitor Promotes Stabilization of HIF-1α via Inhibition of Its Degradation and Exerts Chondroprotective Effects in a Rat Osteoarthritis Model. Int J Mol Sci. 2026;27:7869. PMID: 42737766. MeSH: Osteoarthritis/drug therapy
  4. Chen YX, Zhang F, Ding Y, Zheng MH, Zhou ZA, Qiu L, et al. Advances in drug delivery systems for Osteoarthritis therapy: exosomes, microparticles, nanoparticles, and hydrogels. Discov Nano. 2026;21:440. PMID: 42734879. keyword: Drug delivery systems
  5. Hu H, Li G, Wang Y, Xie S, Cao F, Li H, et al. Secoisolariciresinol diglucoside alleviates inflammatory injury in osteoarthritis chondrocytes through ERBB2-associated JAK2/STAT3 signaling: network pharmacology and experimental validation. Front Immunol. 2026;17:1891212. PMID: 42718780. MeSH: Glucosides/pharmacology
  6. Xia D, Li J, Zhou X, Yu C, Yang S. DOT1L-mediated H3K79me3 of ITCH promotes AURKA ubiquitination to suppress ECM degradation in osteoarthritis. Mol Genet Genomics. 2026;301:188. PMID: 42714638. MeSH: Interleukin-1beta/pharmacology
  7. Chen S, Yang S, He J, Wang Y, Liu Z, Wu J, et al. Chlorogenic acid protects against knee osteoarthritis by targeting the Nrf2/HO-1 redox-ferroptosis axis and inflammatory cartilage degeneration. Int Immunopharmacol. 2026;189:117382. PMID: 42705065. keyword: Immunopharmacology
  8. Ragni E, Taiana M, Landoni S, Valli F, Nebuloni AM, De Luca P, et al. Matrix Protective and Anti-Inflammatory In Vitro Potential of Adipose Mesenchymal Stromal Cell-Derived EVs Coupled With Platelet-Derived Fibrin Gel. Front Biosci (Landmark Ed). 2026;31:54998. PMID: 42689990. MeSH: Anti-Inflammatory Agents/pharmacology
  9. Wang Y, Kang L, Chen K, Jiang Y, Zheng Y, Xu P, et al. ROS-responsive injectable hydrogel enables controlled release of human adipose tissue-derived extracellular vesicles for multifaceted osteoarthritis therapy. J Nanobiotechnology. 2026;24:829. PMID: 42687185. MeSH: Osteoarthritis/drug therapy
  10. Raja K, Suresh DG, Albeshri JK, Rawat SS, Prithishkumar IJ, Nau T, et al. Inflammation-Associated Changes in Piezo1 Expression, Mitophagy-Related Markers, and Matrix Dysregulation in an LPS-Stimulated Co-Culture Organoid System. Cells. 2026;15:1482. PMID: 42645208. MeSH: Lipopolysaccharides/pharmacology
  11. Valerio HP, Corrêa de Melo T, Barbosa de Souza Rizzo M, Teixeira de Melo A, Alvarez-Flores MP, Chudzinski-Tavassi AM. Proteomic Dynamics Reveal Cell-Cycle and Rho GTPase Remodeling Associated with Transient Senescence Traits in Human Chondrocytes During Sustained IL-1β Signaling. Cells. 2026;15:1431. PMID: 42645159. MeSH: Chondrocytes/drug effects
  12. Du G, Wang D, Chen Q, Sun J, Shuai Q, Zhang Q, et al. A stiffness-tunable 3D alginate-collagen-hyaluronic acid model reveals the matrix-dependent chondroprotection of quercetin in osteoarthritis. Biomater Adv. 2026;189:215130. PMID: 42641414. MeSH: Osteoarthritis/drug therapy
  13. Wells LM, Keen JAC, Sharma A, Marr N, Hansen R, Pereira JS, et al. Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis. Bone Res. 2026;14:89. PMID: 42637709. MeSH: Chondrocytes/drug effects
  14. Yang L, Feng J, He W, Huang Y. Prim-O-glucosylcimifugin alleviate osteoarthritis through regulates autophagy via IGF1R/JAK2/STAT3 axis. Phytomedicine. 2026;161:158571. PMID: 42636684. MeSH: Osteoarthritis/drug therapy
  15. Gui Y, Ma R, Ma L, Zou T, Zhang K, Guo X. Fluoride induced chondrocyte extracellular matrix degradation by inhibition of glycolysis by the PHD2/HIF1α signaling pathway. Environ Toxicol Pharmacol. 2026;126:105140. PMID: 42628705. MeSH: Chondrocytes/drug effects
  16. Zhang M, Chen H, Zeng T, Peng B, Yoshitomi T, Kawazoe N, et al. Cell-Cell Interaction of Chondrocytes in Porous Alginate Hydrogels With Different Spatial Cell Distributions and Its Influence on Cell Functions. Adv Healthc Mater. 2026;15:e71592. PMID: 42603865. MeSH: Hydrogels/pharmacology
  17. Dalton J, Divi SN, Eichbaum YK, Luksanapruksa P, Ng MK, Huang R, et al. The Biological Response of Human NP Cells to Soluble Collagen VI. Cells. 2026;15:1339. PMID: 42587749. MeSH: Collagen Type VI/pharmacology
  18. Wei Z, Yu Q, Liao D, Song B, Gou X, Xie Q, et al. Temporal regulation of ascorbic acid synergizes with matrix microenvironment directs chondrogenic commitment and limits hypertrophic differentiation. Biomater Adv. 2026;189:215103. PMID: 42585995. MeSH: Ascorbic Acid/pharmacology
  19. Shao H, Lei Z, Yang W, Zhou J, Li Q, Xu S, et al. Immunomodulatory thermosensitive hydroxypropyl chitin hydrogel platform maintains cartilage-synovium homeostasis for enhanced osteoarthritis therapy. Bioact Mater. 2026;66:1167-1185. PMID: 42571192. keyword: Drug delivery system
  20. Zhang X, Gong C, Zhou J, Zhang Y, Jiang H, Yang Y, et al. Methylnissolin preserves chondrocyte homeostasis and attenuates experimental osteoarthritis through modulation of the PI3K-AKT-NF-κB signaling axis. Int Immunopharmacol. 2026;187:117245. PMID: 42567109. MeSH: Chondrocytes/drug effects
  21. Jiang B, Jiang X, Li S, Niu H, Ji W. Curcumin-Loaded GelMA Microspheres Alleviate Osteoarthritis: Transcriptomic Evidence for Immune Microenvironment Remodeling and ECM Homeostasis Restoration. Chem Biol Drug Des. 2026;108:e70373. PMID: 42543780. MeSH: Curcumin/pharmacology
  22. Maheshwari C, Reddy CB, Kodieswaran M, Nandi SK, Mandal BB. Compartmentalized Dual-Drug Injectable Hydrogel for Anti-Inflammatory Activity and Osteoarthritic Cartilage Repair. Small. 2026;22:e74820. PMID: 42535426. MeSH: Osteoarthritis/drug therapy
  23. Liu Y, Zhang Y, Huang R, Bai L, Liu L, Wang C, et al. Contrasting Effects of HT-2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism. J Biochem Mol Toxicol. 2026;40:e71056. PMID: 42533448. MeSH: Chondrocytes/drug effects
  24. Pan J, Wang X, Gao Y, Ma Y, Ma J, Wang Z. DINCH exposure contributes to osteoarthritis pathogenesis via TSPO-mediated chondrotoxicity: Evidence from in silico prediction to experimental validation. Chem Biol Interact. 2026;437:112266. PMID: 42501774. MeSH: Chondrocytes/drug effects
  25. Dong H, Zhang X, Luo Y, Jin J, Luo Z, Lu Y. Mechanisms and research progress of statins in osteoarthritis. Int Immunopharmacol. 2026;186:117141. PMID: 42468167. MeSH: Osteoarthritis/drug therapy
  26. Noonan KJ, Hunziker EB, Nessler J, Buckwalter JA. Changes in cell, matrix compartment, and fibrillar collagen volumes between growth-plate zones. J Orthop Res. 1998;16:500-8. PMID: 9747793. MeSH: Fluoresceins/pharmacology

Organoids 1

Filed by MeSH heading or keyword; each paper says which one matched. The Organoids page holds the dated feed.

  1. Raja K, Suresh DG, Albeshri JK, Rawat SS, Prithishkumar IJ, Nau T, et al. Inflammation-Associated Changes in Piezo1 Expression, Mitophagy-Related Markers, and Matrix Dysregulation in an LPS-Stimulated Co-Culture Organoid System. Cells. 2026;15:1482. PMID: 42645208. MeSH: Organoids

Publications 105

Filed by MeSH heading or keyword; each paper says which one matched. The Publications page holds the dated feed.

  1. Su H, Zhu Q, Xiang J, Wu Q, Sun W, Fang J, et al. Hierarchical Nanorocket for spatially coordinated regulation of glycosaminoglycan deposition and metabolism in cartilage. Bioact Mater. 2027;68:148-161. PMID: 42733560. research paper
  2. Xie S, Jin C, Ma Y, Luo J, Shen Y, Bai B, et al. Microenvironment-bionic scaffold and multi-cell spatial patterning for area-specific meniscus regeneration. Biomaterials. 2027;336:124468. PMID: 42501741. research paper
  3. Wang ZL, Li HB, Li YT. Combined in vitro microcurrent stimulation and celecoxib suppress NF-κB/NLRP3 signaling and cartilage catabolism in human chondrocytes. Immunol Res. 2026;74:115. PMID: 42789005. research paper
  4. Li Z, Lv Y, Li W, Guo Z, Huang Z, Wei M, et al. Infrapatellar fat pad exosomes promote osteoarthritis by reprogramming macrophage polarization. Biomaterials. 2026;338:124643. PMID: 42785223. research paper
  5. Muiños-López E, Arroyo I, Guaresti O, Urtaza U, Barco-Martín A, Ullate-Agote A, et al. Cellularized Thermoformed Scaffolds with Human Septal Chondrocytes Support In Vivo Cartilage Maturation for Auricular Reconstruction. J Funct Biomater. 2026;17:453. PMID: 42783699. research paper
  6. Vescio RR, Fiordalisi MF, Ambrosio L, Fiorentino D, de Rinaldis E, Di Giacomo G, et al. Irisin in Cartilage Homeostasis: Molecular Mechanisms and Therapeutic Implications for Osteoarthritis. J Funct Morphol Kinesiol. 2026;11:343. PMID: 42783637. research paper
  7. Guo Y, Zhang X, Zhao S, Bian C, Zhu M, Su C, et al. Therapeutic Effects of WIN55,212-2 on Temporomandibular Joint Osteoarthritis in a Rat Model and Primary Temporomandibular Joint Condylar Chondrocytes. Curr Med Chem. 2026. PMID: 42770450. research paper
  8. Wei X, Guan B, He X, Zhu S, Bi R. Role of Notch signaling pathway in joint homeostasis and osteoarthritis. Front Bioeng Biotechnol. 2026;14:1861292. PMID: 42769654. research paper
  9. Shodiev DR, Zvyagina VI, Shchul'kin AV, Marsyanova YA, Ryabova MN, Belskikh ES. Analysis of SUCNR1 in Cartilage Tissue and Its Association with Succinate Metabolism in the Metabolic Phenotype of Osteoarthritis. Bull Exp Biol Med. 2026. PMID: 42768252. research paper
  10. Liu J, Ke H, Su L, Lin Z, Liu C, Jiang S, et al. Yam-Derived Vesicles Alleviate Osteoarthritis via miRNA-Mediated Suppression of the TLR4-TRAF6 Signaling Axis. Small. 2026:e75914. PMID: 42766346. research paper
  11. Das S, Swain P, Swain S, Misra RDK, Rautray TR. Epidemiology and potential mechanisms of structural progression in osteoarthritis. Artif Cells Nanomed Biotechnol. 2026;54:781-818. PMID: 42762435. research paper
  12. Zhang Z, Wang J, Bian H, Chen J, Wang J, Sun Y, et al. Revealing the bioactive components and possible mechanism of Tongbi Lingding in the treatment of osteoarthritis based on UPLC-MS/MS, network pharmacology, transcriptomics, molecular docking, and experimental validation. Naunyn Schmiedebergs Arch Pharmacol. 2026. PMID: 42760374. research paper
  13. Zhang L, Yang X, Yu Y, Yang L. Mammalian cell-derived extracellular vesicles remodel the immune-repair microenvironment in osteoarthritis: from pathological signal transmission to regenerative therapy. Front Immunol. 2026;17:1936617. PMID: 42756019. research paper
  14. Liu YL, Lin YC, Tsai YC, Yen CC, Chiang CY, Hung PJ, et al. Stage-specific MSC spheroid fusion enables bottom-up formation of stage-defined hierarchical cartilage graft. Mater Today Bio. 2026;40:103649. PMID: 42751092. research paper
  15. Xu J, Wang W, Liu L, Wang C, Liu N, Wang X, et al. The application of novel ultrathin iron sulphide nanosheets in the nanotherapy of post-traumatic osteoarthritis. Mater Today Bio. 2026;40:103630. PMID: 42750882. research paper
  16. Ma Z, McEachern L, Lan X, Li DX, Ansari AA, Au I, et al. Oxygen Consumption Rate-Defined Phases Couple Metabolism to Matrix Dynamics in Chondrocyte-Mesenchymal Stromal Cell Co-Culture. FASEB J. 2026;40:e72309. PMID: 42750492. research paper
  17. Zhu G, Yang Y, Ma Y, Wu G, Tian K, He X, et al. Artemotil Attenuates Fibrosis-Associated Chondrocyte Remodelling in Osteoarthritis in Association With STC1-Related TGF-β/SMAD2/3 Signalling. J Cell Mol Med. 2026;30:e71374. PMID: 42747683. research paper
  18. Liang Z, Sun Q, Song D, Jia X, Han C, Han J, et al. Fabrication of a novel carboxymethyl chitosan-manganese complex and its multidimensional regulatory effects on the joint microenvironment in early osteoarthritis. Biomater Adv. 2026;190:215169. PMID: 42743824. research paper
  19. Lu X, Wang Z, Hu W, Hu J, Zou Y. Ginsenoside Rg3 attenuates osteoarthritis progression by modulating the Nrf2-mediated autophagy pathway. Connect Tissue Res. 2026:1-18. PMID: 42742542. research paper
  20. Toumi H, Almhdie-Imjabbar A, Lespessailles E. Piezo1 as a Key Mechanosensitive Ion Channel Linking Mechanical Overload to Mitochondrial Dysfunction, Mitophagy, and Immunometabolic Dysregulation in Osteoarthritis. Cells. 2026;15:1511. PMID: 42738805. research paper
  21. Nakamura K, Fujii Y, Arai Y, Nakagawa S, Inoue A, Cha R, et al. HIF-PH Inhibitor Promotes Stabilization of HIF-1α via Inhibition of Its Degradation and Exerts Chondroprotective Effects in a Rat Osteoarthritis Model. Int J Mol Sci. 2026;27:7869. PMID: 42737766. research paper
  22. Chen YX, Zhang F, Ding Y, Zheng MH, Zhou ZA, Qiu L, et al. Advances in drug delivery systems for Osteoarthritis therapy: exosomes, microparticles, nanoparticles, and hydrogels. Discov Nano. 2026;21:440. PMID: 42734879. research paper
  23. Zhang Z, Li Y, Ye M, Liu H, Huang Q, Wang X, et al. A biomimetic chondrocyte membrane-camouflaged tFNA nanoplatform for reprogramming the cartilage-synovium axis in osteoarthritis. Mater Today Bio. 2026;40:103609. PMID: 42733614. research paper
  24. Li X, Yu X, Li Y, Zhang M, Hao B, Wang X, et al. Microbiota-mediated enhancement of the chondroprotective effects of epimedium polysaccharides: Insights from fermentation and zebrafish models. Int J Biol Macromol. 2026;382:154464. PMID: 42731790. research paper
  25. Liu H, Yao D, Wang Y, Kong Q. SERPINE1/PAI-1 in Skeletal Degeneration: A Proposed Context-Dependent Framework for Bone Remodeling Regulation. Calcif Tissue Int. 2026;117:138. PMID: 42726129. research paper
  26. Oruc MS, Gunenc AC, Yılmaz F, Akdemir O. Molecular modulation of cartilage graft survival: a systematic review and translational synthesis of local and systemic strategies. JPRAS Open. 2026;52:128-137. PMID: 42725065. research paper
  27. Wang Y, Wang Y, Li S, Chen X, Hou Y, Wang C, et al. Eugenol preserves chondrocyte extracellular matrix homeostasis by modulating the ALK1/ALK5-associated TGF-β/Smad signaling axis. Front Pharmacol. 2026;17:1885138. PMID: 42723961. research paper
  28. Kamiloğlu U, Günhan K, Çelik DA, Vatansever HS. Comparative Evaluation of Exosomes, Mesenchymal Stem Cells, and Nanofat on Cartilage Graft Viability in a Rat Model. Aesthetic Plast Surg. 2026. PMID: 42722925. research paper
  29. Khaliji E, Wong TS, Barker CM, Chen S, Cassano JM. Non-coding RNA profiles associated with equine osteoarthritis: a systematic review. Front Vet Sci. 2026;13:1917722. PMID: 42719329. research paper
  30. Hu H, Li G, Wang Y, Xie S, Cao F, Li H, et al. Secoisolariciresinol diglucoside alleviates inflammatory injury in osteoarthritis chondrocytes through ERBB2-associated JAK2/STAT3 signaling: network pharmacology and experimental validation. Front Immunol. 2026;17:1891212. PMID: 42718780. research paper
  31. Zhong H, He Q, Qin F, Shu Y, Wang Y, Yang X, et al. In situ-built chemo-electroactive hydrogel incorporating Mg-based hydrogen generators for osteoarthritis therapy. Mater Today Bio. 2026;40:103604. PMID: 42718625. research paper
  32. Xia D, Li J, Zhou X, Yu C, Yang S. DOT1L-mediated H3K79me3 of ITCH promotes AURKA ubiquitination to suppress ECM degradation in osteoarthritis. Mol Genet Genomics. 2026;301:188. PMID: 42714638. research paper
  33. Wang T, Liu Y. Vestitol Ameliorates Ferroptosis-Associated Features and Osteoarthritis Progression Through Modulation of the GSK3B/Nrf2/GPX4 Pathway. Cell Biochem Biophys. 2026. PMID: 42711652. research paper
  34. Novotný R, Rajzer I, Franková J. In vitro evaluation of hydroxyapatite, β-tricalcium phosphate, graphene oxide and zinc oxide for osteochondral regeneration under inflammatory conditions. Mol Cell Biochem. 2026. PMID: 42709332. research paper
  35. Chen S, Yang S, He J, Wang Y, Liu Z, Wu J, et al. Chlorogenic acid protects against knee osteoarthritis by targeting the Nrf2/HO-1 redox-ferroptosis axis and inflammatory cartilage degeneration. Int Immunopharmacol. 2026;189:117382. PMID: 42705065. research paper
  36. Ji C, Niu C, Liu Q, Chen Y, Zeng Q, Chen Y. Chondroitin sulfate and collagen peptides co-derived from sturgeon cartilage: Characterization and combined effects on IL-1β-induced chondrocyte inflammation in vitro. Int J Biol Macromol. 2026;382:154169. PMID: 42702320. research paper
  37. Yue H, Alhaskawi A, Ezzi SHA, Zhou J. Biologic and regenerative strategies for osteoarthritis: advances in MSC, exosome, and PRP based therapies. Front Pharmacol. 2026;17:1897284. PMID: 42694831. research paper
  38. Ragni E, Taiana M, Landoni S, Valli F, Nebuloni AM, De Luca P, et al. Matrix Protective and Anti-Inflammatory In Vitro Potential of Adipose Mesenchymal Stromal Cell-Derived EVs Coupled With Platelet-Derived Fibrin Gel. Front Biosci (Landmark Ed). 2026;31:54998. PMID: 42689990. research paper
  39. Wang Y, Kang L, Chen K, Jiang Y, Zheng Y, Xu P, et al. ROS-responsive injectable hydrogel enables controlled release of human adipose tissue-derived extracellular vesicles for multifaceted osteoarthritis therapy. J Nanobiotechnology. 2026;24:829. PMID: 42687185. research paper
  40. Piao L, Wang H, Zhang Q, Li J, Sun H, Sun R, et al. Emerging molecular mechanisms of the ECM-exosome growth-plate axis in idiopathic short stature. Front Cell Dev Biol. 2026;14:1898879. PMID: 42682878. research paper
  41. Hansen U. Visualization and Organization of Collagen VI Containing Suprastructures in Articular Cartilage. Methods Mol Biol. 2026;3022:167-178. PMID: 42681157. research paper
  42. Gao S, Huo X, Shen P, Ma J, Ma X. CSNK2A2 drives knee osteoarthritis progression by co-activating the Wnt/β-catenin and NF-κB signaling pathways. Arch Biochem Biophys. 2026;786:110986. PMID: 42674201. research paper
  43. He Y, Li C, Chen K, Wang X, Xu S, Zhou Z, et al. MYDGF as a telomerase activator and therapeutic target for osteoarthritis. Adv Biotechnol (Singap). 2026;4:34. PMID: 42671689. research paper
  44. Zhou R, Li J, Chen S, Meng C, Liu Q, Huang X, et al. Corilagin attenuates osteoarthritis progression by coordinating NF-κB inhibition with PI3K/AKT/mTOR-associated autophagy restoration. Int Immunopharmacol. 2026;188:117342. PMID: 42664894. research paper
  45. He X, Guo M, Lian H, Chen L. Mesenchymal Stem Cell Exosomes in Combination with Hydrogels for Osteoarthritis: From Exploratory Applications to Optimization and Translational Outlook. Curr Issues Mol Biol. 2026;48:764. PMID: 42651763. research paper
  46. Gao J, Xue Z, Qiu H, Chen C, Li C. Bai@Cu-MOF alleviates osteoarthritis by targeting ferroptosis and restoring chondrocyte redox balance. Int J Biol Macromol. 2026;381:154214. PMID: 42648682. research paper
  47. Raja K, Suresh DG, Albeshri JK, Rawat SS, Prithishkumar IJ, Nau T, et al. Inflammation-Associated Changes in Piezo1 Expression, Mitophagy-Related Markers, and Matrix Dysregulation in an LPS-Stimulated Co-Culture Organoid System. Cells. 2026;15:1482. PMID: 42645208. research paper
  48. Valerio HP, Corrêa de Melo T, Barbosa de Souza Rizzo M, Teixeira de Melo A, Alvarez-Flores MP, Chudzinski-Tavassi AM. Proteomic Dynamics Reveal Cell-Cycle and Rho GTPase Remodeling Associated with Transient Senescence Traits in Human Chondrocytes During Sustained IL-1β Signaling. Cells. 2026;15:1431. PMID: 42645159. research paper
  49. Du G, Wang D, Chen Q, Sun J, Shuai Q, Zhang Q, et al. A stiffness-tunable 3D alginate-collagen-hyaluronic acid model reveals the matrix-dependent chondroprotection of quercetin in osteoarthritis. Biomater Adv. 2026;189:215130. PMID: 42641414. research paper
  50. Xu J, Wychowaniec JK, D'Este M, Jiang N, Zhu S, Grad S, et al. Crosslinking strategies govern the morphology and biological performance of decellularized extracellular matrix particle-tyramine-modified hyaluronic acid hydrogels. RSC Adv. 2026. PMID: 42639416. research paper
  51. Wells LM, Keen JAC, Sharma A, Marr N, Hansen R, Pereira JS, et al. Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis. Bone Res. 2026;14:89. PMID: 42637709. research paper
  52. Yang L, Feng J, He W, Huang Y. Prim-O-glucosylcimifugin alleviate osteoarthritis through regulates autophagy via IGF1R/JAK2/STAT3 axis. Phytomedicine. 2026;161:158571. PMID: 42636684. research paper
  53. Zhang R, Zhang W, Ou S, Xu C, Qi Y, Yang Y. VHL/CDO1 axis regulates chondrocyte ferroptosis and knee osteoarthritis progression. Arch Biochem Biophys. 2026;785:110980. PMID: 42632536. research paper
  54. Dong X, Zhang J, Liu S, Zhu J, Zhang P. Application and prospect of zinc oxide nanoparticle-enhanced biomimetic hydrogels in articular cartilage repair. Biochem Biophys Rep. 2026;47:102748. PMID: 42631120. research paper
  55. Yuan S, Chen H, Wei J, Tan J, Liu S, Fu Z. Integrated single-cell and experimental validation links effector chondrocyte-associated oxidative stress to EIF6-related p47phox-NOX2 signaling in osteoarthritis. Front Physiol. 2026;17:1882484. PMID: 42630363. research paper
  56. Gui Y, Ma R, Ma L, Zou T, Zhang K, Guo X. Fluoride induced chondrocyte extracellular matrix degradation by inhibition of glycolysis by the PHD2/HIF1α signaling pathway. Environ Toxicol Pharmacol. 2026;126:105140. PMID: 42628705. research paper
  57. Safiyyu MU, Syed NH, Azlan M, Zain MRAM, Nurul AA. MicroRNAs as Key Regulators of Degeneration and Inflammation in Osteoarthritis: A Narrative Review. Saudi J Med Med Sci. 2026;14:197-208. PMID: 42621662. research paper
  58. Fan M, Li T, Mohan A, Han B, Newton M, Kwok B, et al. Decorin-mediated Extracellular Matrix Stabilization Maintains Cartilage Integrity During Aging. bioRxiv. 2026. PMID: 42619839. research paper
  59. Iqbal Z, Shabbir M, Rasul F, Xia J, Zeng H, Liang Y, et al. Extracellular matrix targeting peptide functionalized plant-derived lipid nanoparticles for gene therapy in osteoarthritis. Chin Med J (Engl). 2026. PMID: 42619364. research paper
  60. Yuan XS, Zhang HJ, Ding JX, Luo ZL, Chen M, Zhang XQ, et al. IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m6A-Dependent Stabilization of ECM1 mRNA. Kaohsiung J Med Sci. 2026:e70280. PMID: 42618981. research paper
  61. Li W, Wang Q, Gu X, Chen M, Xu Q, Li D, et al. Metasurface-enhanced surface plasmon resonance microscopy for long-term label-free monitoring of chondrocyte-biointerface dynamics under mechanical, genetic, and inflammatory perturbations. Colloids Surf B Biointerfaces. 2026;268:116084. PMID: 42607386. research paper
  62. Zhang M, Chen H, Zeng T, Peng B, Yoshitomi T, Kawazoe N, et al. Cell-Cell Interaction of Chondrocytes in Porous Alginate Hydrogels With Different Spatial Cell Distributions and Its Influence on Cell Functions. Adv Healthc Mater. 2026;15:e71592. PMID: 42603865. research paper
  63. Widowati W, Lydia L, Rumayauw J G, Wijaya MP, Caroline S S M, Putera JH, et al. Secretome Derived from Umbilical Cord Mesenchymal Stem Cells as a Therapeutic Approach for Osteoarthritis: Insights from In Vitro, In Vivo, and Clinical Evidence. Cell Biochem Biophys. 2026;84:3319-3332. PMID: 42601565. research paper
  64. Luo F, Yuan X, Zhou H, Wang Q, Chen C, Ling Y, et al. Extracellular vesicle-mediated immune crosstalk in rheumatoid arthritis synovium: mechanistic insights and translational challenges. Front Immunol. 2026;17:1891984. PMID: 42598067. research paper
  65. Tang R, Yin J, Li S, Wang S, Fei J, Zhou Z. Mitochondrial dysfunction as a key mediator of endplate chondrocyte senescence: emerging insights and targeted interventions. Exp Gerontol. 2026;223:113276. PMID: 42595025. research paper
  66. Wang Z, Shi X, Yang G, Zheng K, Xu R. Sex hormones and their receptors in osteoarthritis: current research progress. Ann Jt. 2026;11:43. PMID: 42591740. research paper
  67. Turner ML, Fattouh AS, Whitaker IS. The Effect of Physical, Biochemical, and Electrical Culture Conditions on Articular Chondrocytes Used for Cartilage Tissue Engineering: A Narrative Review. Int J Mol Sci. 2026;27:6661. PMID: 42589319. research paper
  68. Dalton J, Divi SN, Eichbaum YK, Luksanapruksa P, Ng MK, Huang R, et al. The Biological Response of Human NP Cells to Soluble Collagen VI. Cells. 2026;15:1339. PMID: 42587749. research paper
  69. Schulz A, Brockmann EM, Zentgraf M, Baur AS, Uebe S, Ekici AB, et al. A single-donor proof-of-concept single-cell analysis maps heterogeneous differentiation trajectories toward cartilage-like states in human urine-derived stem cells. Stem Cell Res Ther. 2026;17:276. PMID: 42587306. research paper
  70. Wei Z, Yu Q, Liao D, Song B, Gou X, Xie Q, et al. Temporal regulation of ascorbic acid synergizes with matrix microenvironment directs chondrogenic commitment and limits hypertrophic differentiation. Biomater Adv. 2026;189:215103. PMID: 42585995. research paper
  71. Pavlovich RI. Avascularity, Cartilaginous Matrix Composition, and Glycolytic Metabolism in Articular Cartilage and the Inner Meniscus: A Mechanobiological Trade-off With Testable Predictions. Cartilage. 2026:19476035261478272. PMID: 42579815. research paper
  72. Shao H, Lei Z, Yang W, Zhou J, Li Q, Xu S, et al. Immunomodulatory thermosensitive hydroxypropyl chitin hydrogel platform maintains cartilage-synovium homeostasis for enhanced osteoarthritis therapy. Bioact Mater. 2026;66:1167-1185. PMID: 42571192. research paper
  73. Zhou Q, Shen Q, Gao Z, Shi W, Guo Q. HRX-215 attenuates cartilage fibrosis in osteoarthritis progression and microfracture repair by targeting MKK4. Biochem Pharmacol. 2026;254:118336. PMID: 42570848. research paper
  74. Qiwei F, Jiahua S, Shu C, Jia C, Haobo L, Jun Z. Epigenetic-metabolic coupling by SOX3/WDR5-SIRT5 signaling mediates the therapeutic effects of TGFβ-targeted exosomal nanoparticles in osteoarthritis. Mater Today Bio. 2026;39:103457. PMID: 42569264. research paper
  75. Zhang X, Gong C, Zhou J, Zhang Y, Jiang H, Yang Y, et al. Methylnissolin preserves chondrocyte homeostasis and attenuates experimental osteoarthritis through modulation of the PI3K-AKT-NF-κB signaling axis. Int Immunopharmacol. 2026;187:117245. PMID: 42567109. research paper
  76. Mai L, Zhu R, Liu Y, Feng J, Huang M, Yin M, et al. Mechanism of RORα in promoting osteoarthritis through p53 deubiquitination-mediated chondrocyte ferroptosis. iScience. 2026;29:116939. PMID: 42565176. research paper
  77. Liu X, Luo X, Xiang L, Jiang D, Zhang G, Ge Z. Dynamic change of extracellular matrix of knee articular cartilage during porcine development. Tissue Cell. 2026;104:103833. PMID: 42561533. research paper
  78. Faraldo NC, Ribeiro MDS, Apolonio EVP, Ferrari LC, Portugal LC, de Moura FBC, et al. Optimizing osteochondral decalcification and histological processing in ovine joint models. Braz J Vet Med. 2026;48:e013925. PMID: 42553617. research paper
  79. Zhang Z, Zhang C, Ju Y, Zhou Y, Guo W, Xie J, et al. Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming. Proc Natl Acad Sci U S A. 2026;123:e2602136123. PMID: 42546205. research paper
  80. Yang J, Kubav A. Circular RNAs orchestrate molecular networks in osteoarthritis: From miRNA sponging to epigenetic and exosome-mediated regulation. Mol Biol Rep. 2026;53:1322. PMID: 42545381. research paper
  81. Jiang B, Jiang X, Li S, Niu H, Ji W. Curcumin-Loaded GelMA Microspheres Alleviate Osteoarthritis: Transcriptomic Evidence for Immune Microenvironment Remodeling and ECM Homeostasis Restoration. Chem Biol Drug Des. 2026;108:e70373. PMID: 42543780. research paper
  82. Maheshwari C, Reddy CB, Kodieswaran M, Nandi SK, Mandal BB. Compartmentalized Dual-Drug Injectable Hydrogel for Anti-Inflammatory Activity and Osteoarthritic Cartilage Repair. Small. 2026;22:e74820. PMID: 42535426. research paper
  83. Yang F, Wang Q, Zhu X, Yao Y, Yu T, Xiao X. Energy crisis and cartilage collapse: metabolic reprogramming of chondrocytes in osteoarthritis. Front Immunol. 2026;17:1834080. PMID: 42534542. research paper
  84. Liu Y, Zhang Y, Huang R, Bai L, Liu L, Wang C, et al. Contrasting Effects of HT-2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism. J Biochem Mol Toxicol. 2026;40:e71056. PMID: 42533448. research paper
  85. Zhang L, Xing X, Zhou C, Fu F, Chen Z, Wu C, et al. Sophoridine attenuates osteoarthritis progression: association with suppression of chondrocyte pyroptosis via inhibiting NF-κB signaling pathway. Front Pharmacol. 2026;17:1861567. PMID: 42528752. research paper
  86. Dilek Y, Rios JL, O'Riordan C, Bruggink V, Warmink K, Muenzebrock KA, et al. Spatial and longitudinal monitoring of cartilage and intervertebral disc extracellular matrix formation using proteoglycan building blocks and click chemistry: specificity, quantification, and detection upon subcutaneous implantation. Acta Biomater. 2026;222:274-288. PMID: 42526826. research paper
  87. Jain M, Anuja AK, Yadav S, Ara J, Ojha A, Chaturvedi CP. Non-coding RNA in osteoarthritis: mechanistic insights and future perspectives. Front Endocrinol (Lausanne). 2026;17:1851589. PMID: 42523837. research paper
  88. Mou Y, Tian T, Wang P, Wang X, Li W, Tang W, et al. Compressive stress-driven mechanosignaling in chondrocytes: From molecular mechanism to scaffold engineering and translational opportunities. Mater Today Bio. 2026;39:103453. PMID: 42518697. research paper
  89. Zhao Y, Liu X. Epigenetic regulation in osteoarthritis: recent updates and emerging mechanisms. Front Genet. 2026;17:1862466. PMID: 42517028. research paper
  90. Li Y, Xue R, Congdon S, Abbazia M, Zhou T, Wong T, et al. Cartilage-Specific Has2 Deletion Uncovers an Important Role for Hyaluronan in Cartilage and Joint Integrity. Biomedicines. 2026;14:1461. PMID: 42511936. research paper
  91. Ziverec A, Grangy J, Pécheux Y, Vertu-Ciolino D, Farndale R, Leitinger B, et al. Triple-helical ligands for collagen-binding proteins improve cartilage extracellular matrix production in nasal chondrocytes. Mater Today Bio. 2026;39:103434. PMID: 42502817. research paper
  92. Pan J, Wang X, Gao Y, Ma Y, Ma J, Wang Z. DINCH exposure contributes to osteoarthritis pathogenesis via TSPO-mediated chondrotoxicity: Evidence from in silico prediction to experimental validation. Chem Biol Interact. 2026;437:112266. PMID: 42501774. research paper
  93. Chang Y, Kong K, Jin M, Liu S, Yang Y, Zhu Y, et al. Artificial Chlorella Biohybrids for Alleviation of Cartilage Degeneration in Osteoarthritis. Exploration (Beijing). 2026;6:20250125. PMID: 42494574. research paper
  94. Wang P, Tang W, Mou Y, Wang X, Li W, Niloy NR, et al. Mechanical sensing of fluid shear stress biphasically regulates chondrocyte metabolism and osteoarthritis progression: Implications for therapeutics. Prog Biophys Mol Biol. 2026;201:265-273. PMID: 42492727. research paper
  95. Hao D, Lu W, Wang F, Zhang L. Exercise therapy-associated changes in Periostin (POSTN) osteoarthritis are linked to Hippo-YAP signaling. Mol Biol Rep. 2026;53:1232. PMID: 42484941. research paper
  96. Swami P, Goldman Z, Alba B, Andriamifidy HF, Liang H, Haque S, et al. Tissue engineering of articular cartilage using nasal chondrocytes on alginate-chitosan-based composite scaffolds. Cell Tissue Bank. 2026;27:39. PMID: 42484720. research paper
  97. Li T, Zheng A, Zhu C, Li Y, Yang Z, Tang X, et al. Mitochondria-targeted MXene-based nanozymes promote mitophagy and inhibit mtDNA-triggered cGAS/STING inflammation in osteoarthritis. Bioact Mater. 2026;66:412-427. PMID: 42473606. research paper
  98. Kulyar MF, Pachaleva J, Brazaite S, Akhtar M, Hasan MM, Kaboli S, et al. Signal-driven interplay between lipid peroxidation and ferroptosis orchestrates osteoarthritis degeneration. J Orthop Translat. 2026;60:101178. PMID: 42471867. research paper
  99. Dong H, Zhang X, Luo Y, Jin J, Luo Z, Lu Y. Mechanisms and research progress of statins in osteoarthritis. Int Immunopharmacol. 2026;186:117141. PMID: 42468167. research paper
  100. Ai X, Zhu C, Xie Y, Luo X, Zhang C. ITGB1-Mediated Focal Adhesion Signaling Underlies the Chondroprotective Effects of Extracorporeal Shockwave Therapy in Knee Osteoarthritis. Am J Phys Med Rehabil. 2026;105:704-713. PMID: 42468008. research paper
  101. Paggi CA, Porsul I, Le Gac S, Karperien M. Effects of Compression on Extracellular Matrix Synthesis by Chondrocytes and Chondrosarcoma Cells. Cartilage. 2026:19476035261460455. PMID: 42464887. research paper
  102. Sabucedo-Suárez A, Muñoz F, Permuy M, Fernández-Martín S, Cantalapiedra-González A, López-Peña M. 27-Week avocado-soybean unsaponifiables treatment in a knee osteoarthritis rabbit model: histomorphometric assessment of potential disease-modifying effects. Front Vet Sci. 2026;13:1821515. PMID: 42290786. research paper
  103. Wilusz RE, Sanchez-Adams J, Guilak F. The structure and function of the pericellular matrix of articular cartilage. Matrix Biol. 2014;39:25-32. PMID: 25172825. research paper
  104. Noonan KJ, Hunziker EB, Nessler J, Buckwalter JA. Changes in cell, matrix compartment, and fibrillar collagen volumes between growth-plate zones. J Orthop Res. 1998;16:500-8. PMID: 9747793. research paper
  105. Buckwalter JA, Mankin HJ. Articular cartilage: tissue design and chondrocyte-matrix interactions. Instr Course Lect. 1998;47:477-86. PMID: 9571449. research paper