Spatial transcriptomics
Where each chondrocyte state sits in the tissue. Single-cell and spatial omics mapped onto the zones.
Single-cell RNA sequencing of knee OA cartilage identifies distinct chondrocyte subpopulations including progenitor-like, regulatory, hypertrophic and fibrocartilage-like states.
Bisphenol A (BPA) exposure drives chondrocyte lipid peroxidation and ferroptosis, linking environmental endocrine disruption to OA comorbidity with fatty liver.
Review joining transcriptomic and metabolomic layers by cell type in OA.
August 2026 review integrating scRNA-seq and spatial data for OA; identifies actionable pathway targets
Spatial data places CRIP1+ preHTC at pathological niches alongside prefibroblasts; confirmed as diagnostic candidate
From PubMed
Asking PubMed for every paper on the chondrocyte in this section.